Smoking remains a leading factor of preventable death and disease. We will also explore current opportunities and challenges in conducting pharmacogenomic research on smoking cessation that encourages greater participant diversity, including practical barriers to clinical utilization of pharmacological smoking cessation treatment and clinical implementation of pharmacogenetic knowledge. We will summarize results by race, ethnicity, and ancestry across pharmacological treatments and study designs. This scoping review examines the extent to which racial, ethnic, and ancestral groups that experience differences in smoking rates and smoking cessation are represented in the existing body of published pharmacogenetic studies of smoking cessation. Therefore, clinical application of pharmacogenetic results may exacerbate health inequities by racial and ethnic groups.
This suggests that much of the current pharmacogenetic study results for smoking cessation may not apply to all populations.
These results may not adequately capture the variability across all smokers as a result of understudied differences in allele frequencies across genetic ancestry populations. In particular, genetic variants associated with pharmacological responses to smoking cessation treatment have generally been conducted in populations with participants that self-identify as White race or who are determined to be of European genetic ancestry. The use of tailored smoking cessation strategies that incorporate information on individual-level social and genetic factors hold promise, although additional pharmacogenomic knowledge is still needed. Clinical treatment of nicotine dependence also continues to be challenged by individual-level variability in effectiveness to promote abstinence. In addition, the prevalence of cessation attempts and abstinence differs by individual-level social factors such as race and ethnicity. 4Department of Public Health, Brody School of Medicine, East Carolina University, Greenville, United StatesĪbstinence rates among smokers attempting to quit remain low despite the wide availability and accessibility of pharmacological smoking cessation treatments.3Department of Integrative Life Sciences, Virginia Commonwealth University, Richmond, VA, United States.2Department of Family Medicine and Population Health, Virginia Commonwealth University, Richmond, VA, United States.1Division of Epidemiology, Department of Family Medicine and Population Health, Virginia Commonwealth University, Richmond, VA, United States.Delk 1, Sanya Surya 1, Shambhavi Bhati 1 and James Clifford 4 Edmondson 1, Mariam Sankoh 3, Brendan Jamieson 1, Kayla J.
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